A numerical study into minimal conditions of arterial vasomotion
The occlusion of arteries during ischeamia causes a state of insufficient blood supply and hypoperfusion in downstream to keep the brain functioning. Hypoperfusion in human brain is a critical event which leads to cerebral hypoxia with high risk of developing impairment. Vasomotion can be induced in the above situation of reduced perfusion. This might increase the blood flow by decreasing the effective vascular resistance and lead to enhanced perfusion. Therefore, one could assume that vasomotion is a regulating mechanism associated with hypoperfusion to control vascular resistance, blood flow and tissue perfusion. It is therefore important to explore the underlying mechanisms and the factors affecting the initiation and spread of vasomotion. In future, this study will help the early diagnosis and treatment of previously mentioned pathological conditions. This study analyses the minimum condition required to initiate vasomotion. It is shown that a minimum number of cells need to be stimulated with sufficient amount of depolarization to initiate conduction of contraction.