Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies (2019)

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Type of Content
Journal ArticlePublisher
Springer Science and Business Media LLCISSN
2045-2322Language
engCollections
- Science: Journal Articles [1192]
Authors
Abstract
In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.
Citation
Pacilè S, Dullin C, Baran P, Tonutti M, Perske C, Fischer U, Albers J, Arfelli F, Dreossi D, Pavlov K, Maksimenko A, Mayo SC, Nesterets YI, Taba ST, Lewis S, Brennan PC, Gureyev TE, Tromba G, Wienbeck S (2019). Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies. Scientific Reports. 9(1). 13762-.This citation is automatically generated and may be unreliable. Use as a guide only.
Keywords
Breast; Humans; Breast Neoplasms; Tomography, X-Ray Computed; Mastectomy; Feasibility Studies; Radiation Dosage; Phantoms, Imaging; Synchrotrons; Female; Cone-Beam Computed TomographyANZSRC Fields of Research
40 - Engineering::4003 - Biomedical engineering51 - Physical sciences::5105 - Medical and biological physics
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Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies
Pacilè S; Dullin C; Baran P; Tonutti M; Perske C; Fischer U; Albers J; Arfelli F; Dreossi D; Pavlov K; Maksimenko A; Mayo SC; Nesterets YI; Taba ST; Lewis S; Brennan PC; Gureyev TE; Tromba G; Wienbeck S (Springer Science and Business Media LLC, 2019)© 2019, The Author(s). In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different ... -
Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography
Pacilè S; Baran P; Dullin C; Dimmock M; Lockie D; Missbach-Guntner J; Quiney H; McCormack M; Mayo S; Thompson D; Nesterets Y; Hall C; Pavlov K; Prodanovic Z; Tonutti M; Accardo A; Fox J; Tavakoli Taba S; Lewis S; Brennan P; Hausermann D; Tromba G; Gureyev T (2018)© International Union of Crystallography, 2018 The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer ... -
Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography
Aminzadeh A; Arhatari BD; Maksimenko A; Hall CJ; Hausermann D; Peele AG; Fox J; Kumar B; Prodanovic Z; Dimmock M; Lockie D; Nesterets YI; Thompson D; Mayo SC; Paganin DM; Taba ST; Lewis S; Brennan PC; Quiney HM; Gureyev TE; Pavlov, Konstantin (Institute of Electrical and Electronics Engineers (IEEE), 2022)Breast microcalcifications are an important primary radiological indicator of breast cancer. However, microcalcification classification and diagnosis may be still challenging for radiologists due to limitations of the ...