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    The regulation of 3-deoxy-D-arabino-heptulosonate 7 phosphate synthase from Mycobacterium tuberculosis.

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    Blackmore_N_Use_of_thesis_form_2014.pdf (61.27Kb)
    Author
    Blackmore, Nicola Jean
    Date
    2015
    Permanent Link
    http://hdl.handle.net/10092/10242
    Thesis Discipline
    Biochemistry
    Degree Grantor
    University of Canterbury
    Degree Level
    Doctoral
    Degree Name
    Doctor of Philosophy

    Allosteric regulation of important enzymes is a mechanism frequently employed by organisms to exert control over their metabolism. The shikimate pathway is ultimately responsible for the biosynthesis of the aromatic amino acids in plants, microorganisms and apicomplexans. Two enzymes of the pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) and chorismate mutase (CM) are located at critical positions along the aromatic amino acid biosynthetic pathway and are often tightly feedback regulated in order to control the flux of metabolites through the pathway. This research presents studies on the allosteric function of these two enzymes. These studies emphasise the complexity of the intersecting network of allosteric response, which alters the catalytic activity of each enzyme in response to metabolic demand for the aromatic amino acids.

    Subjects
    DAH7PS
     
    allostery
     
    enzymes
     
    regulation
     
    chromate mutate
     
    shikimate pathway
    Collections
    • Science: Theses and Dissertations [3604]
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