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    Effect of x-ray energy on the radiological image quality in propagation-based phase-contrast computed tomography of the breast (2021)

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    Type of Content
    Journal Article
    UC Permalink
    https://hdl.handle.net/10092/102335
    
    Publisher's DOI/URI
    http://doi.org/10.1117/1.jmi.8.5.052108
    
    Publisher
    SPIE-Intl Soc Optical Eng
    ISSN
    2329-4302
    Collections
    • Science: Journal Articles [1139]
    Authors
    Wan S
    Arhatari BD
    Nesterets YI
    Mayo SC
    Thompson D
    Fox J
    Kumar B
    Prodanovic Z
    Hausermann D
    Maksimenko A
    Hall C
    Dimmock M
    Lockie D
    Rickard M
    Gadomkar Z
    Aminzadeh A
    Vafa E
    Peele A
    Quiney HM
    Lewis S
    Gureyev TE
    Brennan PC
    Taba ST
    Pavlov, Konstantin cc
    show all
    Abstract

    Purpose: Breast cancer is the most common cancer in women in developing and developed countries and is responsible for 15% of women’s cancer deaths worldwide. Conventional absorption-based breast imaging techniques lack sufficient contrast for comprehensive diagnosis. Propagation-based phase-contrast computed tomography (PB-CT) is a developing technique that exploits a more contrast-sensitive property of x-rays: x-ray refraction. X-ray absorption, refraction, and contrast-to-noise in the corresponding images depend on the x-ray energy used, for the same/fixed radiation dose. The aim of this paper is to explore the relationship between xray energy and radiological image quality in PB-CT imaging. Approach: Thirty-nine mastectomy samples were scanned at the imaging and medical beamline at the Australian Synchrotron. Samples were scanned at various x-ray energies of 26, 28, 30, 32, 34, and 60 keV using a Hamamatsu Flat Panel detector at the same object-to-detector distance of 6 m and mean glandular dose of 4 mGy. A total of 132 image sets were produced for analysis. Seven observers rated PB-CT images against absorption-based CT (AB-CT) images of the same samples on a five-point scale. A visual grading characteristics (VGC) study was used to determine the difference in image quality. Results: PB-CT images produced at 28, 30, 32, and 34 keV x-ray energies demonstrated statistically significant higher image quality than reference AB-CT images. The optimum x-ray energy, 30 keV, displayed the largest area under the curve ðAUCVGCÞ of 0.754 (p ¼ 0.009). This was followed by 32 keV (AUCVGC ¼ 0.731, p ≤ 0.001), 34 keV (AUCVGC ¼ 0.723, p ≤ 0.001), and 28 keV (AUCVGC ¼ 0.654, p ¼ 0.015). Conclusions: An optimum energy range (around 30 keV) in the PB-CT technique allows for higher image quality at a dose comparable to conventional mammographic techniques. This results in improved radiological image quality compared with conventional techniques, which may ultimately lead to higher diagnostic efficacy and a reduction in breast cancer mortalities.

    Citation
    Wan S, Arhatari BD, Nesterets YI, Mayo SC, Thompson D, Fox J, Kumar B, Prodanovic Z, Hausermann D, Maksimenko A, Hall C, Dimmock M, Pavlov KM, Lockie D, Rickard M, Gadomkar Z, Aminzadeh A, Vafa E, Peele A, Quiney HM, Lewis S, Gureyev TE, Brennan PC, Taba ST (2021). Effect of x-ray energy on the radiological image quality in propagation-based phase-contrast computed tomography of the breast. Journal of Medical Imaging. 8(05).
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Keywords
    phase-contrast CT; propagation-based phase-contrast imaging; breast cancer diagnosis; breast cancer; x-ray energies
    ANZSRC Fields of Research
    34 - Chemical sciences::3406 - Physical chemistry::340605 - Molecular imaging (incl. electron microscopy and neutron diffraction)
    32 - Biomedical and clinical sciences::3202 - Clinical sciences::320222 - Radiology and organ imaging
    32 - Biomedical and clinical sciences::3211 - Oncology and carcinogenesis::321102 - Cancer diagnosis
    Rights
    All rights reserved unless otherwise stated
    http://hdl.handle.net/10092/17651

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