Development of a Discrete Spectrometric NIR Reflectance Glucometer

Type of content
Journal Article
Thesis discipline
Degree name
Publisher
Elsevier BV
Journal Title
Journal ISSN
Volume Title
Language
en
Date
2020
Authors
Campbell JD
Holder-Pearson, Lui
Benton C
Chase, Geoff
Pretty, Christopher
Knopp, Jennifer
Abstract

Abstract: Currently, there are no continuous, non-invasive blood glucose monitors. With over 366 million people worldwide expected to be diagnosed as diabetic by 2030, an alternative to the current invasive methods is critical. This paper investigates the use of a discrete spectometric, NIR reflectance glucometer to detect a change in glucose concentration in solution. At each wavelength, an LED is used to emit light, and a reverse-biased LED detects light using wavelengths 660 nm, 850 nm, 940 nm, 1450 nm, 1550 nm, 1650 nm. The discharge time of a reverse-biased LED is proportional to the temporal integral of the detected light intensity. The sensor’s response to changing glucose concentration was tested in both water and porcine blood. Glucose concentration was increased by 0.5 mmol l−1 and compared with a finger stick glucometer. Each wavelength exhibited an expected change in adsorption given only an increase in glucose concentration. The inverted exponential increase in absorption is explained by Beer Lambert’s law. Wavelengths 660 nm, 850 nm and 1450 nm showed minimal change to absorption, while 940 nm, 1550 nm and 1650 nm showed considerable change in absorption. The 1550 nm LED gave the greatest increase in absorption with a 7% rise over 4.3 mmol l−1 to 20.6 mmol l−1. Ratios of absorption responses (R1550/1650, R1550/1450 and R940/850) each gave proportional increases in absorption with increasing glucose concentrations.

Description
Citation
Campbell JD, Holder-Pearson L, Pretty CG, Benton C, Knopp J, Chase JG (2020). Development of a Discrete Spectrometric NIR Reflectance Glucometer. IFAC-PapersOnLine. 53(2). 15970-15975.
Keywords
discrete NIR spectrometry, non-invasive, glucose sensor, LED-LED detection, Beer Lambert's Law
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Fields of Research::40 - Engineering::4003 - Biomedical engineering::400308 - Medical devices
Fields of Research::40 - Engineering::4003 - Biomedical engineering::400305 - Biomedical instrumentation
Fields of Research::40 - Engineering::4009 - Electronics, sensors and digital hardware::400909 - Photonic and electro-optical devices, sensors and systems (excl. communications)
Fields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinology
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