A microfluidic platform for applying localized and dynamically-controlled compression on cancer cells
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Conference Contributions - Published
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Date
2019
Authors
Onal, Sevgi
Alkaisi, Maan
Nock, Volker
Abstract
In this work we report a microfluidic cell-culture platform with an integrated, actively-modulated actuator for the application of compressive forces on cancer cells. We show fabrication of the platform, mechanical characterization of the actuator and observed mechanotactic behavior of a monolayer of SKOV-3 ovarian cancer cells under static conditions. We further show compression and lysing of the cells, demonstrating suitability for mechanical stimulation with various pressures to study compressive forces in cancer microenvironments.
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Citation
Onal S, Alkaisi MM, Nock V (2019). A microfluidic platform for applying localized and dynamically-controlled compression on cancer cells. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 640-641.
Keywords
Microfluidics, Micro-piston, Localized and controlled compression, Cancer cells
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Fields of Research::32 - Biomedical and clinical sciences::3211 - Oncology and carcinogenesis::321101 - Cancer cell biology
Fields of Research::40 - Engineering::4012 - Fluid mechanics and thermal engineering::401203 - Biomedical fluid mechanics
Fields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering
Fields of Research::40 - Engineering::4012 - Fluid mechanics and thermal engineering::401203 - Biomedical fluid mechanics
Fields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering
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