Altered blood glucose dynamics during and after anhepatic phase of liver transplantation: a model-based approach

Abstract

During liver transplantation (LT) the glucose metabolism is effected by a crucial disturbance. The blood glucose level is extremely hard to control by conventional clinical protocols during this phase. Model based approach can enhance the blood glucose control during the anhepatic phase and postanhepatic phase. The physiological constants of validated clinical metabolic model were slightly modified based on previous studies. The model fitting errors and the sufficient capture of the blood glucose (BG) dynamic evincived the applicability of the model. However the particular/sufficient per-patient estimation of endogenous production could more enhance the performance of the model based BG prediction.