Addressing Inter-patient Variability in DPIs: Optimizing Powder Entrainment using CFD-guided DPI Design

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Conference Contributions - Published
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2018
Authors
Murnane D
Kopsch T
Symons D
Abstract

As portable devices dry powder inhalers (DPIs) are an attractive inhalation therapy option for patients who struggle with inhalation coordination of pressurized metered dose inhalers. DPIs also offer flexibility for aerosolization and delivery of high drug payloads, including the introduction of inhaled insulin and antibiotic products to the market [1, 2]. There is also an intensive interest in developing bioequivalent (generic) DPI products as established products reach the end of patent exclusivity, and this has been particularly evident within the developing pharmaceutical markets, e.g. Revolizer™ or Starhaler™ device platforms. There is a continuing requirement for enhanced methodologies to improve the design process for DPI products; including offering a more rapid lock-down of design features, matching the performance of innovator products and, most excitingly, developing devices that minimize variability in product performance between patients.

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Citation
Murnane D, Kopsch T, Symons D (2018). Addressing Inter-patient Variability in DPIs: Optimizing Powder Entrainment using CFD-guided DPI Design. Kerala, India: RDD Asia 2018. 14/11/2018-16/11/2018. 1. 73-82.
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Fields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering
Fields of Research::32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320103 - Respiratory diseases
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