Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO2 composite scaffold (2018)
Type of ContentJournal Article
AuthorsBakhsheshi-Rad, H.R., Hamzah, E., Staiger, M.P., Dias, G.J., Hadisi, Z., Saheban, M., Kashefian, M.show all
© 2017 Mg-Ca-TiO2 (MCT) composite scaffolds loaded with different concentrations of doxycycline (DC) with a network of interconnected pores with good compressive strength (5 ± 0.1 MPa) were fabricated via space holder method for the first time. The results showed that MCT-DC scaffolds possess a porosity and pore size in the range of 65–67% and 600–800 μm respectively. The bioactivity results exhibited the apatite formation on the MCT-DC scaffold surface, indicating that DC did not obstruct the bioactivity of MCT. The MCT-DC scaffolds drug release profiles show the initial burst and sustained drug release (55–75%) and the release rate could be adjusted via altering the DC concentration. The MCT loaded with 1 and 5% DC did not indicate cytotoxic behavior against MG63 cells while further DC loading resulted in some toxicity. Antimicrobial properties of MCT-DC scaffolds against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria were examined and the results reveal oblivious inhibition zone around each MCT-DC scaffold whereas no obvious inhibition is observed around the MCT scaffold. Therefore, MCT-DC composite scaffolds with low concentration of DC could be alternative candidates for infection prevention and bone tissue engineering.
CitationBakhsheshi-Rad HR, Hamzah E, Staiger MP, Dias GJ, Hadisi Z, Saheban M, Kashefian M (2018). Drug release, cytocompatibility, bioactivity, and antibacterial activity of doxycycline loaded Mg-Ca-TiO<inf>2</inf> composite scaffold. Materials and Design. 139. 212-221.
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