While the literature surrounding the negative effects of stress on health and well-being is plentiful, there is a distinct lack of research applying stress frameworks to an organisational safety context. This study investigated the impact of stressors and strains on safety in the workplace, using the Job Demand-Control model as a research framework. In order to maintain a proactive approach to safety management, safety climate, safety compliance and safety participation were used as study variables as they have been established as antecedents to accidents and injuries in the workplace. From questionnaire data from employees with regular safety issues it was found that a positive relationship exists between safety climate and safety behaviours. Satisfaction was found to mediate the relationship between safety climate and one dimension of the safety compliance measure used. Providing support for the buffer hypothesis of the Job Demand-Control model, safety control moderated the relationship between safety climate and safety participation. Control over work scheduling, and decision latitude moderated the relationship between safety climate and safety participation but were indicative of an enhancing effect, rather than a buffering effect. The results suggest that control is an important variable to consider in terms of safety.